Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5280262 | Tetrahedron Letters | 2005 | 5 Pages |
Abstract
A highly efficient one-pot two-step microwave procedure was developed for the synthesis of 1-aryl-1H-indazoles. Microwave heating of 2-halobenzaldehydes or 2-haloacetophenones with phenylhydrazines at 160 °C for 10 min quantitatively yielded the arylhydrazones, which were further cyclized to give 1-aryl-1H-indazoles via CuI/diamine-catalyzed N-arylation under microwave heating (160 °C, 10 min). Good to excellent yields were observed for 2-iodo, 2-bromo, and 2-chloro benzaldehydes or acetophenones.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Chittari Pabba, Hong-Jun Wang, Susan R. Mulligan, Zhen-Jia Chen, Todd M. Stark, Brian T. Gregg,