| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5280284 | Tetrahedron Letters | 2005 | 4 Pages |
Abstract
Boc-phenyl piperidine and Boc-phenyl pyrrolidine are selectively lithiated at the 2-position and trapped with a variety of electrophiles. The chemistry is used to make a sub-nanomolar inhibitor of the human neurokinin 1 receptor.
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Dong Xiao, Brian J. Lavey, Anandan Palani, Cheng Wang, Robert G. Aslanian, Joseph A. Kozlowski, Neng-Yang Shih, Andrew T. McPhail, Gerard P. Randolph, Jean E. Lachowicz, Ruth A. Duffy,