TBSOTf-assisted three component coupling of epoxides, THF, and ylides derived from the phosphoniosilylation products of enones and α,β-unsaturated lactones

Ylides 3, derived from the phosphoniosilylation products of enones and α,β-unsaturated lactones, were reacted with epoxides 4 and TBSOTf in THF. Interestingly, the three component coupling products 5–8 were obtained after subsequent desilylation.

Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slide