| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5280327 | Tetrahedron Letters | 2007 | 4 Pages |
Abstract
A practical stereoselective 5-exo-trig radical cyclization procedure was developed in order to prepare enantiomerically pure GABA derivative precursors (4-alkyl-pyrrolidin-2-ones). This procedure allows much more rapid access to optically pure GABA derivatives, such as the powerful antiepileptic agent (S)-(+)-3-aminomethyl-5-methylhexanoic acid (Pregabaline).
Related Topics
Physical Sciences and Engineering
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Organic Chemistry
Authors
Verónica RodrÃguez, Leticia Quintero, Fernando Sartillo-Piscil,