Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5280406 | Tetrahedron Letters | 2010 | 4 Pages |
Abstract
The interesting examples of chiral phosphoric acid-catalyzed regio- and enantioselective arylation of α,β-unsaturated trifluoromethyl ketones were reported. The reaction proceeded well and the desired products were obtained in good yields (up to 99%) with moderate to good enantioselectivities (up to 88% ee). Several desired products were obtained with excellent optical purities after a single recrystallization. Subsequent reduction of enantiopure products with NaBH4 afforded two diastereomers of chiral trifluoromethyl-substituted secondary alcohols with high enantioselectivities (98% ee).
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Authors
Zeng-kai Pei, Yan Zheng, Jing Nie, Jun-An Ma,