| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5280421 | Tetrahedron Letters | 2008 | 4 Pages |
Abstract
The antimalarial guided fractionation of the culture of marine Streptomyces sp. strain H668 led to the isolation of a new polyether metabolite. The structure was determined by comprehensive NMR and MS assignments. This new metabolite showed in vitro antimalarial activity against both the chloroquine-susceptible (D6) and-resistant (W2) clones of Plasmodium falciparum, without cytotoxicity to normal cells (Vero) making it a promising first lead from this marine bacterium.
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Physical Sciences and Engineering
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Authors
MinKyun Na, Damaris A.F. Meujo, Dion Kevin, Mark T. Hamann, Matthew Anderson, Russell T. Hill,