| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5280604 | Tetrahedron Letters | 2008 | 4 Pages |
Abstract
A highly efficient palladium-catalyzed Heck coupling reaction of heteroaryl halides with electron-rich vinyl ether and hydroxyalkyl vinyl ethers is described. It was found that the choice of solvent, ligand, and reaction temperature had a fundamental influence on the regioselectivity and reactivity of the reaction, and the combination of Pd(OAc)2 and DPPF in ethylene glycol led to the most effective catalytic system. Under these conditions, a variety of heteroaryl halides reacted very quickly with electron-rich olefins to afford exclusively the branched products in good to excellent yields without employing triflates, halide scavengers, or ionic liquids.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Dan Xu, Zhihua Liu, Weijun Tang, Lijin Xu, Zeynab Hyder, Jianliang Xiao,