| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5280611 | Tetrahedron Letters | 2008 | 5 Pages |
Abstract
Water as a solvent significantly accelerates the addition of various amines to diethyl vinylphosphonate to yield β-aminophosphonates without any catalyst compared to known procedures for such aza-Michael reactions. The products are obtained in quantitative yields and high purity over short reaction times. Using a reactant ratio (vinylphosphonate/amine) of 2:1 resulted in double phosphorylation of primary amines.
Graphical abstractRemarkable rate acceleration is reported for the aza-Michael reaction of diethyl vinylphosphonate with amines in water to yield β-aminophosphonates in quantitative yields.Download full-size image
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Ekaterina V. Matveeva, Pavel V. Petrovskii, Irina L. Odinets,