Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5280686 | Tetrahedron Letters | 2005 | 4 Pages |
Abstract
Crown ether-type macrocycles consisting of an enantiopure biarenol derivative and an oligoethylene glycol were synthesized by the Lewis acid-mediated tandem Claisen rearrangement. This is the first example of the successful application of the tandem Claisen rearrangement to the synthesis of enantiopure macrocyclic biarenol derivatives. The enantiopure macrocyclic biarenols were found to form 1:1 complexes with amino acid salts and to discriminate their chirality.
Graphical abstractDownload full-size image
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Hiroaki Yoshida, Yuka Kobayashi, Kazuhisa Hiratani, Kazuhiko Saigo,