| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5280751 | Tetrahedron Letters | 2008 | 4 Pages |
The synthesis of a new class of 1,2,4-oxadiazole-linked orthogonally urethane-protected dipeptide mimetics is described. The protocol employs a reaction between an N-protected amino acyl fluoride and an amino acid-derived amidoxime. All the three commonly employed urethanes have been used in this protocol for N-protection. The course of the reaction was found to be high yielding and all new compounds were well characterized by NMR and mass spectroscopy. The O-acyl amidoxime intermediate has also been isolated as a stable solid.
Graphical abstractA new class of 1,2,4-oxadiazole-linked orthogonally urethane-protected dipeptide mimetics has been synthesized by reaction between an N-protected amino acyl fluoride and an amino acid-derived amidoxime.Download full-size image
