Article ID Journal Published Year Pages File Type
5280857 Tetrahedron Letters 2010 4 Pages PDF
Abstract
Morita-Baylis-Hillman acetates undergo smooth allylic nucleophilic substitution (SN2′) with tosylmethyl isocyanide (TosMIC) in the presence of a catalytic amount of BF3·OEt2 under mild conditions to furnish trisubstituted olefins in high yields with (E)-stereoselectivity.
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Physical Sciences and Engineering Chemistry Organic Chemistry
Preview
The allylic nucleophilic substitution of Morita-Baylis-Hillman acetates with isocyanides: a facile synthesis of trisubstituted olefins
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