| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5280912 | Tetrahedron Letters | 2005 | 4 Pages |
Abstract
The synthesis of various functionalized or spirobicyclic glutarimides by a novel tandem process has been disclosed. The reaction involves a base-catalyzed Michael addition of active methylene compounds to secondary conjugated amides, followed by intramolecular N-acylation of the carboxamido group. It provides a relatively general and simple access to useful synthetic intermediaries and potentially active pharmacological compounds. In addition, a novel group of spirobicyclic systems has been synthesized.
Graphical abstractTwelve examples of spirobicyclic or 3-substituted glutrarimides.Download full-size image
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Jelena B. PopoviÄ-ÄorÄeviÄ, Milovan D. IvanoviÄ, Vesna D. KiricojeviÄ,