| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5280994 | Tetrahedron Letters | 2008 | 4 Pages |
Abstract
A selective and practical bromine-metal exchange process under non-cryogenic conditions was developed by a simple modification of an existing protocol. By directly adding an alkyl lithium RLi reagent to a solution of a bromoaryl substrate ArBr and an alkylmagnesium reagent RMgX, a lithium triarylmagnesiate Ar3MgLi complex formed that allowed for various types of functionalization and more elaborate cross-coupling reactions. The simplicity and improved safety of the method represent a significant improvement over current state of the art that uses lithium trialkylmagnesiate R3MgLi complexes, and is especially advantageous for large-scale synthesis.
Graphical abstractDownload full-size image
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Fabrice Gallou, Ruedi Haenggi, Hans Hirt, Wolfgang Marterer, Frank Schaefer, Manuela Seeger-Weibel,