Stereoselective synthesis (+)-cephalosporolide D

A simple and efficient stereoselective synthesis of macrolactone, (+)-cephalosporolide D has been accomplished in 13 steps from inexpensive and commercially available starting materials in an overall yield of 17%, respectively. This convergent synthesis utilizes Maruoka asymmetric allylation reaction, Grubb's cross metathesis for the formation of a fully functionalized acid, and Yamaguchi lactonization as key steps.

Graphical abstractA simple and efficient stereoselective synthesis of (+)-cephalosporolide D is described.Download full-size image