| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5281089 | Tetrahedron Letters | 2007 | 4 Pages |
Abstract
A new method for the preparation of clarithromycin is described through the highly regioselective O-methylation at C(6)-OH of the novel derivative 9-pyrimidyloxime erythromycin A. The facile synthesis of 6,11-O-dimethyl- and 6,11,12-O-trimethyl erythromycin A is also reported.
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Ernesto Brunet, Dulce MarÃa Muñoz, Francisco Parra, Susana Mantecón, Olga Juanes, Juan Carlos RodrÃguez-Ubis, Ma Carmen Cruzado, Ramón Asensio,