| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5281099 | Tetrahedron Letters | 2007 | 4 Pages |
Abstract
A linear synthesis of the glucuronide metabolite of ABT-751 was replaced with a convergent synthesis that features direct glycosidic coupling between the aglycone and a trichloroacetimidate glucuronyl donor. Structural elucidation of a unique and unexpected difluoroboron complex of the desired glycosidic coupling product along with optimization of the synthetic steps is described.
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Authors
Kenneth M. Engstrom, Rodger F. Henry, Ian Marsden,