Synthesis of 3,5-disubstituted 1,2,4-oxadiazoles as peptidomimetic building blocks

Twelve new 1,2,4-oxadiazole based compounds have been synthesized. Their structures contain a protected amine and a carboxyl or an ester group, and thus serve as potential peptidomimetic building blocks. The synthetic route is simple and mild conditions are used so that the chirality of the starting amino acids is retained.

Graphical abstractTwelve new 1,2,4-oxadiazole based compounds have been synthesized, using a simple and efficient synthetic route to afford enantiopure compounds in good yields.Download full-size image