| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5281232 | Tetrahedron Letters | 2010 | 4 Pages |
Abstract
A novel and efficient asymmetric route to CP-734432, a lactam analog of PGE2, that shows selective agonism against the EP4 receptor subtype, is reported herein. The key steps include a Heck coupling to introduce the aryl ring at C-16 and a highly diastereoselective Sharpless asymmetric dihydroxylation to set the C-15 center.
Graphical abstractA novel and efficient asymmetric route to CP-734432, a lactam analog of PGE2, that shows selective agonism against the EP4 receptor subtype, is reported herein. The key steps include a Heck coupling to introduce the aryl ring at C-16 and a highly diastereoselective Sharpless asymmetric dihydroxylation to set the C-15 center.Download full-size image
Related Topics
Physical Sciences and Engineering
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Authors
Sajiv K. Nair, Jean J. Matthews, Stephan J. Cripps, Chunrong Ma, Elena Z. Dovalsantos, Alan W. Grubbs, Neal W. Sach, Wolter ten Hoeve, Han Koster, Erik J. Flahive, Steven P. Tanis, Matt Renner, Jim van Wiltenburg,