| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5281233 | Tetrahedron Letters | 2010 | 4 Pages |
Abstract
Kinamycin D is a potent antitumor antibiotic; however the biological mode of action is poorly understood. Recent efforts suggest the natural product is capable of generating reactive oxygen species under acidic pH to induce DNA damage in the presence of a reducing agent.
Graphical abstractKinamycin D is a potent antitumor antibiotic; however the biological mode of action is poorly understood. Recent efforts suggest the natural product is capable of generating reactive oxygen species under acidic pH to induce DNA damage in the presence of a reducing agent.Download full-size image
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Authors
Christine L. Heinecke, Christian Melander,