| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5281259 | Tetrahedron Letters | 2007 | 4 Pages |
Abstract
The HETPHOX ligand class was applied to the rhodium-catalysed asymmetric hydrosilylation of a range of substituted acetophenones. Enantioselective hydrosilylation of acetophenone with the tert-butyl substituted HETPHOX ligand gave (R)-phenylethanol in excellent enantioselectivity (84% ee) and in good conversion (80%). When applied to the hydrosilylation of other ketones conversions up to 93% and enantioselectivities up to 88% were observed.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Anthony G. Coyne, Patrick J. Guiry,