Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5281272 | Tetrahedron Letters | 2007 | 4 Pages |
Abstract
Racemic 4-(substituted-1H-1,2,3-triazol-1-yl), 4-aryl and 4-(arylmethyl)tetrazolyl-pyroglutamic and proline derivatives were synthesized from dimethyl-2,4-dibromoglutaryle 1 in good yield using mild reaction conditions. The key step for the preparation of the triazole substituted molecule was the 1,3-dipolar cycloaddition of an acetylenic compound with an azido derivative. The tetrazole derivatives were prepared by the selective N2-alkylation of 5-substituted tetrazoles with 1.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Fatimazohra Lenda, Farhate Guenoun, Jean Martinez, Frédéric Lamaty,