| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5281277 | Tetrahedron Letters | 2007 | 4 Pages |
Abstract
A three step, convergent synthesis of 4-aryl-3-pyrrolin-2-ones from a tetramic acid has been developed. The key transformation utilized a Suzuki-Miyaura cross-coupling reaction between a 4-tosyloxy-3-pyrrolin-2-one and an arylboronic acid. This work also provides access to 4-arylpyrrolidin-2-ones, cyclic analogs of γ-aminobutyric acid (GABA). Hydrogenation of 4-(4â²-chlorophenyl)-3-pyrrolin-2-one proceeded smoothly to give baclofen lactam.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Sarah J.P. Yoon-Miller, Suzanne M. Opalka, Erin T. Pelkey,