| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5281282 | Tetrahedron Letters | 2007 | 5 Pages |
Abstract
Preparation of peptide thioester is essential for native chemical ligation and block condensation. Our novel methodology involves conversion of the carboxylic acid of a peptide into a thioester using p-toluenesulfonyl isocyanate, followed by alkylation, then thiol substitution. Our methodology can also be used for the preparation of glycopeptide thioesters. Furthermore, it is possible to carry out the reaction as a sequential peptide chemical ligation.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Shino Manabe, Tomoyuki Sugioka, Yukishige Ito,