Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5281323 | Tetrahedron Letters | 2008 | 4 Pages |
Abstract
Introduction of the acetylene group on the 1,3,5-triazine scaffold was studied under various conditions. We describe here a new method to functionalize a triazine ring using Sonogashira coupling between 2-benzylsulfanyl-4,6-dichloro-1,3,5-triazine and trimethylsilylacetylene to give the corresponding 2-benzylsulfanyl-4-chloro-6-(trimethylsilyl)ethynyl-1,3,5-triazine. The latter was then used to obtain phosphoric acid mono-{4-[4-(4-amino-6-benzylsulfanyl-1,3,5-triazin-2-yl)-1,2,3-triazol-1-yl]-phenyl} ester via click chemistry by Huisgen 1,3-dipolar cycloaddition reaction.
Graphical abstractDownload full-size image
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Caroline Courme, Sophie Gillon, Nohad Gresh, Michel Vidal, Christiane Garbay, Jean-Claude Florent, Emmanuel Bertounesque,