Article ID Journal Published Year Pages File Type
5281323 Tetrahedron Letters 2008 4 Pages PDF
Abstract

Introduction of the acetylene group on the 1,3,5-triazine scaffold was studied under various conditions. We describe here a new method to functionalize a triazine ring using Sonogashira coupling between 2-benzylsulfanyl-4,6-dichloro-1,3,5-triazine and trimethylsilylacetylene to give the corresponding 2-benzylsulfanyl-4-chloro-6-(trimethylsilyl)ethynyl-1,3,5-triazine. The latter was then used to obtain phosphoric acid mono-{4-[4-(4-amino-6-benzylsulfanyl-1,3,5-triazin-2-yl)-1,2,3-triazol-1-yl]-phenyl} ester via click chemistry by Huisgen 1,3-dipolar cycloaddition reaction.

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Physical Sciences and Engineering Chemistry Organic Chemistry
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