Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5281432 | Tetrahedron Letters | 2007 | 4 Pages |
Abstract
(2R,3S)-α-Methylenelactam 3, the key intermediate in Corey's syntheses of salinosporamide A, has been synthesized from (S)-methyl 2-hydroxymethylpyroglutamate through chemoselective O-protection, regio- and stereoselective N-methylnitrone cycloaddition and quaternarization-elimination reactions as the main steps.
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Virginie Caubert, Julien Massé, Pascal Retailleau, Nicole Langlois,