| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5281473 | Tetrahedron Letters | 2008 | 4 Pages |
Abstract
4â³,6â³-Didehydro-cADPcR (3), an unsaturated carbocyclic ribose analog of a Ca2+-mobilizing second messenger cyclic ADP-ribose (cADPR), was designed and successfully synthesized using a key intramolecular condensation reaction forming the 18-membered pyrophosphate ring structure with a S-phenyl phosphorothioate-type substrate. Biological evaluation showed that 4â³,6â³-didehydro-cADPcR is a potent Ca2+-mobilizing agent in T cells.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Takashi Kudoh, Karin Weber, Andreas H. Guse, Barry V.L. Potter, Minako Hashii, Haruhiro Higashida, Mitsuhiro Arisawa, Akira Matsuda, Satoshi Shuto,