Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5281481 | Tetrahedron Letters | 2008 | 4 Pages |
Abstract
An enantiodivergent strategy for the synthesis of trans-3,4-disubstituted succinimides is reported. The key step is a highly trans-stereoselective SmI2-induced Reformatsky-type reaction of 4-substituted-O-benzoylated malimides with carbonyl compounds. Double chirality transmissions were performed with good to excellent diastereoselectivities.
Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry