| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5281486 | Tetrahedron Letters | 2008 | 4 Pages |
Abstract
2-Quinolones are prepared from o-aminophenylketones by N-acylation with phosphonoalkanoylchlorides, followed by an intramolecular Horner-Wadsworth-Emmons olefination. The transformation proceeds under mild conditions, is generally applicable, gives good yields and can be performed either in two steps or as a one-pot reaction.
Graphical abstract2-Quinolones are prepared by an acylation/HWE olefination sequence, which can be performed as a one-pot reaction. This method is applicable to enolisable aminoketones as starting materials. A wide range of substituents are tolerated.Download full-size image
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Jens-Uwe Peters, Tony Capuano, Silja Weber, Stéphane Kritter, Matthias Sägesser,