| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5281580 | Tetrahedron Letters | 2010 | 4 Pages |
Abstract
Two new pentacyclic indole alkaloids, lirofolines A and B, possessing a novel rearranged ibogan ring system, are obtained from two Malayan Tabernaemontana species (Tabernaemontana corymbosa and Tabernaemontana divaricata) and the structures are established by analysis of the spectroscopic data. A biomimetic partial synthesis of lirofoline A from ibogaine via the Polonovski reaction is carried out. Lirofolines A and B showed significant activity in reversing multidrug resistance in vincristine-resistant KB cells (IC50 3.4 and 7.5 μg/ml, respectively).
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Yun-Yee Low, Kuan-Hon Lim, Yeun-Mun Choo, Huey-Shen Pang, Tadahiro Etoh, Masahiko Hayashi, Kanki Komiyama, Toh-Seok Kam,