| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5281607 | Tetrahedron Letters | 2010 | 4 Pages |
Abstract
The conversion of 23-nor-5,20(22)E-choladienic acid-3β-ol and other intermediates of the putative norcholanic acid pathway of cardenolide biosynthesis by recombinant 3β-hydroxysteroid dehydrogenase from Digitalis lanata in dehydrogenation and reduction reactions was investigated. 23-nor-4,20(22)E-choladienic acid-3-one was found to be a substrate of recombinant progesterone 5β-reductases from D. lanata and Arabidopsis thaliana. The role of various substrates in cardenolide biosynthesis is discussed.
Graphical abstractNorcholanic acids are substrates of two enzymes supposed to be involved in cardenolide biosynthesis.Download full-size image
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Pia Schebitz, Lars Nothdurft, Andreas Hensel, Frieder Müller-Uri, Wolfgang Kreis,