Article ID Journal Published Year Pages File Type
5281737 Tetrahedron Letters 2006 5 Pages PDF
Abstract

A series of substituted quinolines was developed via the Friedländer reaction employing microwave irradiation (MW), in the presence of a catalytic amount of hydrochloric acid. The products were obtained in good yields in 1.5-12 min and were tested in vitro against the parasites causative of malaria, leishmaniasis, sleeping sickness and Chagas' disease (TDR, WHO). Some of these compounds exhibited activity against Plasmodium falciparum and others resulted moderately active against Trypanosoma cruzi.

Graphical abstractDownload full-size image

Related Topics
Physical Sciences and Engineering Chemistry Organic Chemistry
Authors
, , , , ,