Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5281738 | Tetrahedron Letters | 2006 | 4 Pages |
Abstract
Among a number of DMF dialkyl acetals investigated for the regioselective synthesis of 3-acylindolizines, the di-t-butyl acetal, via its iminium intermediate readily formed in situ, provides the highest chemoselectivity for the intermolecular cyclization of picolinium salts. DMF di-t-butyl acetal was applied to the syntheses of a variety of 3-acylated indolizines including alkyl, aryl, and heteroaryl substituents.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Zhiqiang Xia, Teresa Przewloka, Keizo Koya, Mitsunori Ono, Shoujun Chen, Lijun Sun,