| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5281752 | Tetrahedron Letters | 2006 | 5 Pages |
Abstract
An improved method for the N-alkylation of primary amines with primary and secondary alcohols has been developed. Novel, effective catalyst systems, for example, Ru3(CO)12 combined with tri-o-tolylphosphine or n-butyl-di-1-adamantylphosphine, allow for aminations in a good yield under comparatively mild conditions.
Graphical abstractThe N-alkylation of primary amines with primary and secondary alcohols proceeds smoothly in the presence of in situ generated ruthenium catalysts such as Ru3(CO)12/tri-o-tolylphosphine or n-butyl-di-1-adamantylphosphine.Download full-size image
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Annegret Tillack, Dirk Hollmann, Dirk Michalik, Matthias Beller,