| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5281864 | Tetrahedron Letters | 2009 | 4 Pages |
Starting from readily available o-phenylenediamines 1, ketones 2 and isocyanides 3, a variety of highly substituted 3,4-dihydroquinoxalin-2-amine derivatives 4 were efficiently synthesized in the presence of catalytic amount of cerium(IV) ammonium nitrate at room temperature. The flexibility of this protocol also opens a new route to the structurally unique spirocyclic analogs when cyclic ketones are employed.
Graphical abstractStarting from readily available o-phenylenediamines 1, ketones 2 and isocyanides 3, a variety of highly substituted 3,4-dihydroquinoxalin-2-amine derivatives 4 were efficiently synthesized in the presence of catalytic amount of cerium(IV) ammonium nitrate at room temperature. The flexibility of this protocol also opens a new route to the structurally unique spirocyclic analogs when cyclic ketones are employed.Download full-size image
