Article ID Journal Published Year Pages File Type
5281916 Tetrahedron Letters 2008 4 Pages PDF
Abstract

An efficient synthesis of polyfunctionalized 4H-pyrans is carried out in one pot through condensation of an aldehyde, malononitrile, and an active methylenic diketo compound using a heterogeneous strong basic Mg/La mixed oxide catalyst. The protocol offers advantages in terms of higher yields, short reaction times, and mild reaction conditions, with reusability of the catalyst.

Graphical abstractAn efficient, heterogeneous strong basic Mg/La catalyst is studied for the synthesis of polyfunctionalized pyran derivatives in a single step by simple condensation of an aldehyde, malononitrile, and diketoesters. The reaction is operated under mild conditions and the catalyst can be recycled.Download full-size image

Related Topics
Physical Sciences and Engineering Chemistry Organic Chemistry
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