| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5282016 | Tetrahedron Letters | 2006 | 5 Pages |
Abstract
Aminomethyl-polystyrene resins were prepared using FeCl3-nitromethane and FeCl3-benzophenone complexes as Friedel-Crafts catalysts. All the resins were highly loaded and functionalized with Rink amide linker. A comparative synthesis of the classic difficult sequence ACP (65-74) on the prepared resins by Fmoc/t-Bu chemistry is presented. The target peptide of highest purity (91%) was that prepared using FeCl3-nitromethane.
Graphical abstractACP (65-74) was prepared on aminomethyl-resin synthesized using a FeCl3-nitromethane complex in high purity (91%).Download full-size image
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Christos Zikos, George Alexiou, Nicolas Ferderigos,