| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5282066 | Tetrahedron Letters | 2009 | 4 Pages |
Abstract
The scope and limitations of SNAr substitution reactions of metalated 4-cyanopiperidines with heterocyclic halides were explored. These facile reactions provide rapid access to a wide range of 4-heteroaryl-4-cyanopiperidines and have resulted in improved yields, faster reaction times, and lower temperatures than previously published synthetic methods.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Ronald K. Chang, Christina N. Di Marco, Daniel R. Pitts, Thomas J. Greshock, Scott D. Kuduk,