| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5282068 | Tetrahedron Letters | 2009 | 4 Pages |
Abstract
Reaction of N-alkyl-N-arylsulfonyl-2-halo-propionamides with pentamethyldiethylenetriamine and either CuBr or CuCl leads to 2-aryl propionamides via initial radical generation, 1,4-aryl migration with loss of SO2 and reduction of the intermediate amidyl radical in 40-99% yields.
Graphical abstractReaction of N-alkyl-N-arylsulfonyl-2-halo-propionamides with pentamethyldiethylenetriamine and either CuBr or CuCl leads to 2-aryl propionamides in 40-99% yields.Download full-size image
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Andrew J. Clark, Stuart R. Coles, Alana Collis, David R. Fullaway, Nicholas P. Murphy, Paul Wilson,