| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5282282 | Tetrahedron Letters | 2006 | 4 Pages |
Abstract
The reaction of an α-arylcarboxylic acid with TBS-Cl and LiHMDS in THF yielded bis-silyl ketene acetal, which was directly fluorinated with inexpensive Selectfluor® to produce the corresponding α-fluoro-α-arylcarboxylic acid in high yield. The application of this cost-efficient α-fluorination methodology to the synthesis of α-fluorocarboxylic ester from the corresponding carboxylic ester is also described.
Related Topics
Physical Sciences and Engineering
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Authors
Fei Zhang, Jake Z. Song,