| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5282535 | Tetrahedron Letters | 2009 | 5 Pages |
Abstract
Activity-guided fractionation of Erythrophleum succirubrum for TRAIL resistance-overcoming activity led to the isolation of four new cassaine diterpenoid dimers, named erythrophlesins A-D (1-4). Their structures were elucidated by spectral data to show that they have an unsymmetrical dimeric structure through an ester bond between two cassaine diterpenoids. These new compounds were revealed to have a significant reversal effect on TRAIL resistance in human gastric adenocarcinoma (AGS) cells.
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Takashi Miyagawa, Takashi Ohtsuki, Takashi Koyano, Thaworn Kowithayakorn, Masami Ishibashi,