Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5282796 | Tetrahedron Letters | 2006 | 4 Pages |
Abstract
Oligodeoxyribonucleotides that contain a novel nucleoside, 2â²-O-(2-hydrazinoethyl)uridine, were synthesised by NaBH3CN reduction of hydrazones formed from 2â²-O-(2-oxoethyl)oligonucleotides with FmocNHNH2, followed by concd aq NH3 deprotection. The 2â²-hydrazine oligonucleotides obtained were then used to synthesise a number of conjugates with aldehydes via hydrazone formation and with1,3-diketones via pyrazole formation. The method was shown to be applicable for the preparation of oligonucleotide-peptide conjugates.
Related Topics
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Authors
Timofei S. Zatsepin, Michael J. Gait, Tatiana S. Oretskaya, Dmitry A. Stetsenko,