Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5283195 | Tetrahedron Letters | 2007 | 5 Pages |
Abstract
A modular approach to novel 6-amino-7-hydroxysubstituted hexahydro-benzo[1,4]oxazin-3-ones has been developed. The method involves a sequential ring-opening of trans-1,4-cyclohexadiene dioxide with amino nucleophiles. The resultant mono-epoxide from benzylamine was converted to a general electrophilic precursor, which enables the parallel treatment with amino nucleophiles to obtain a series of cyclohexane-fused morpholin-3-ones.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Matthias Scheunemann, Dietlind Sorger, Elena Kouznetsova, Osama Sabri, Reinhard Schliebs, Barbara Wenzel, Jörg Steinbach,