| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5283375 | Tetrahedron Letters | 2006 | 4 Pages |
Abstract
An amide derived from penicillin V and racemic (R/S)-2-aminobutanol was prepared with 83% de and shows significantly higher toxicity than the pure diastereomers prepared from homochiral 2-aminobutanol. This has been attributed to conformational changes in the resolved product brought about through hydrogen-bonded self-assembly in the intermediate.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Peter Styring, Sannie S.F. Chong,