Solid-phase synthesis development of a thymidinyl and 2′-deoxyuridinyl Ugi library for anti-bacterial agent screening

A solid-phase synthesis has been developed to make a thymidinyl and 2′-deoxyuridinyl library starting from 5′-azidonucleosides using Ugi chemistry in 96-well filter plates. A 1344 member library was synthesized for anti-bacterial screening.