| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5284023 | Tetrahedron Letters | 2008 | 4 Pages |
Abstract
A novel organocatalytic highly enantioselective nitrocyclopropanation reaction of α,β-unsaturated aldehydes is presented. The 1-nitro-2-formylcyclopropane derivatives synthesized from this catalytic transformation were converted to the corresponding β-nitromethyl-acid esters, which are excellent precursors of GABA analogues such as Baclofen, by subsequent organocatalytic chemoselective ring-opening.
Related Topics
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Authors
Jan Vesely, Gui-Ling Zhao, Agnieszka Bartoszewicz, Armando Córdova,