| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5284333 | Tetrahedron Letters | 2008 | 5 Pages |
Abstract
We developed a new methodology for the asymmetric Reformatsky-type reaction of (â)-menthyl bromodifluoroacetate (2) with imine in the presence of RhCl(PPh3)3. Ester 2 with the cost-effective chiral auxiliary gave (S)-difluoro-β-lactams in moderate to good yields and high diastereoselectivities through spontaneous removal of the auxiliary.
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Atsushi Tarui, Daiki Ozaki, Naoko Nakajima, Yuto Yokota, Yasser S. Sokeirik, Kazuyuki Sato, Masaaki Omote, Itsumaro Kumadaki, Akira Ando,