Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5284349 | Tetrahedron Letters | 2008 | 4 Pages |
Abstract
A facile asymmetric synthesis of the octalactin lactone was developed staring from (R)-cyclohexylideneglyceraldehyde (1). The key step of the synthesis is an In-mediated diastereoselective crotylation of 1 in water, which furnished the building blocks with the required stereochemistry under operationally simple conditions. Their conversion to the appropriate intermediates, invertive esterification and a ring closing metathesis reaction furnished the target compound.
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Anubha Sharma, Sunita Gamre, Siddharth Roy, Dibakar Goswami, Angshuman Chattopadhyay, Subrata Chattopadhyay,