| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5284454 | Tetrahedron Letters | 2005 | 5 Pages |
Abstract
New 4-aminoquinolines having a -CF2CH-(heteroaryl)-OH moiety are obtained in moderate yields from the electrochemical catalyzed reaction of the corresponding 4-amino-3-chlorodifluoroacetyl-2-methoxyquinoline in the presence of heteroaryl aldehydes. A one-pot intramolecular zinc mediated aromatic nucleophilic substitution also gave access to novel difluorinated 5-aminodihydropyrano[2,3-b]quinolin-4-ones.
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Authors
Maurice Médebielle, Stéphane Hohn, Etsuji Okada, Hidehiko Myoken, Dai Shibata,