Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5284484 | Tetrahedron Letters | 2006 | 5 Pages |
Abstract
Cinchonidine catalyzed the cyclopropanation reaction between chloromethyl ketones and β-substituted methylidenemalononitriles to give trans-cyclopropanes with enantioselectivity up to 82% ee. Experimental evidence suggests that cinchonidine functions as a chiral Brønsted base catalyst in the reaction and hydrogen bonding is essential for inducing high enantioselectivity.
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Satoshi Kojima, Maki Suzuki, Akito Watanabe, Katsuo Ohkata,