Nafion-H mediated selective deprotection of terminal isopropylidene acetals and trityl ethers. Application in the synthesis of a substituted piperidone

Nafion-H acts as an excellent reagent for the deprotection of a variety of terminal isopropylidenes and trityl ethers without affecting the other protecting groups. A facile synthesis of a biologically important piperidone derivative has been achieved via selective deprotection, reductive amination and cyclization.